- Based on these observations, toxicity seems to be due to a lower expression of OAT4 in dogs. Vomiting and diarrhea are often the first clinical signs of grape or raisin toxicity. They often develop within a few hours of ingestion. Pieces of grapes or raisins may be present in the vomitus or stool.
Signs of grape toxicity typically occur within 6-12 hours of ingestion, Fox says. Additionally, she explains that notable effects on the kidneys are seen within 24-48 hours. When a dog stops urinating altogether, Leicester says, this indicates severe kidney failure. At this point, the prognosis is a lot worse. Fox says the critical time for veterinary care is right after your dog eats a grape. Published
- All members of the Vitis spp are potentially toxic. Grape toxicity is unpredictable this means that some dogs can spend their lives eating as many grapes as they like and nothing will ever happen, and other dogs can get severe life-threatening kidney failure from eating a single grape.

- All grapes and products containing grapes, in any amount, can be highly toxic to your dog. Eating grapes can lead to kidney failure or even death in dogs. If you suspect your dog has eaten grapes, you should contact your veterinarian as soon ...
Due to varying amounts of the toxins in grapes and raisins, theres no telling how many grapes it takes to create a toxic dose. Some dogs will go into kidney failure after consuming a small amount, while others will have no side effects after eating a lot more.

- Research has shown that the toxic agent is apparently in the grape itself. That means that seedless or peeled grapes are not safe. Grape poisoning affects different dogs differently. One grape can be deadly for some dogs, and other dogs can eat a dozen with no ill effects.