Abstract Dopaminergic signaling in striatum is strongly implicated in executive functions including cognitive flexibility. However, there is a paucity of multimodal research in humans defining the nature of relationships between endogenous dopamine, striatal network activity, and cognition.
Scientists have confirmed a neurobiochemical link between dopamine and cognitive flexibility. PET imaging shows that the brain increases dopamine production when completing cognitively demanding...

Dopaminergic signaling in striatum is strongly implicated in executive functions including cognitive flexibility. However, there is a paucity of multimodal research in humans defining the nature of relationships between endogenous dopamine, striatal network activity, and cognition.

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Effects of dopamine on cognitive flexibility and stability are reviewed to illustrate how the major ascending neuromodulatory systems that originate from the midbrain dynamically regulate key computational tradeoffs depending on the changing demands of our environment.

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Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility.