Pancreatic islets maintain glucose homeostasis through coordinated action of their constituent endocrine and affiliate cell types and are central to type 2 diabetes (T2D) genetics and pathophysiology. Our understanding of robust human islet cell type-specific alterations in T2D remains limited. Here, we report comprehensive single cell transcriptome profiling of 245,878 human islet cells from ...
Clinical resource with information about Islet cell adenomatosis and its clinical features, MAFA, available genetic tests from US and labs around the world and links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, clinicaltrials.gov, PharmGKB
Two studies published in this issue of Nature Metabolism show that the DNA methylome in islet and cells changes with ageing and the development of T2D.
Most large studies to date have followed up children at high HLA or familial risk via frequent islet autoantibodies testing throughout childhood. Although sensitive and specific, these approaches are not cost-effective for prediction of population-wide type 1 diabetes.
Diagnosis of Type 1 Diabetes: The presence of islet cell cytoplasmic autoantibodies (ICA), glutamic acid decarboxylase autoantibodies (GADA), insulinoma-2 associated autoantibodies (IA-2A) and/or zinc transporter 8 autoantibodies (ZnT8A) in the serum of patients who have been biochemically diagnosed with diabetes mellitus indicates the presence ...
Diabetes study reveals previously overlooked genes tied to disease, pointing to new therapies Article | Khushdeep Bandesh, Ph.D.; Romy Kursawe, Ph.D.; and Efthymios Motakis, Ph.D. analyze type 2 diabetes (T2D) islet data in the microscopy lab at The Jackson Laboratory for Genomic Medicine in Farmington, CT. .
